Congratulations to the publication of “Structural insights into human CCAN complex assembled onto DNA" in Cell Discovery
12-23,2022
Structural insights into human CCAN complex assembled onto DNAIn mitosis, accurate chromosome segregation depends on kinetochores that connect centromeric chromatin to spindle microtubules. The centromeres of budding yeast, which are relatively simple, are connected to individual microtubules via a kinetochore constitutive centromere associated network (CCAN). However, the complex centromeres of h...
Congratulations to the publication of “SIRT2 functions as a histone delactylase and inhibits the proliferation and migration of neuroblastoma cells” in Cell Discovory.
06-07,2022
SIRT2 functions as a histone delactylase and inhibits the proliferation and migration of neuroblastoma cellsLysine lactylation (Kla) was identified as a new type of histone acylation when breast cancer cells were under hypoxia or macrophages were exposed to bacterial challenge. Similar to other fatty acids, lactate reacts with coenzyme A to form lactyl-CoA, and Kla deposition is then catalyze...
Congratulations to the publication of “Structural insights into the recognition of histone H3Q5 serotonylation by WDR5” in Science Advances.
06-18,2021
Structural insights into the recognition of histone H3Q5 serotonylation by WDR5Serotonylation of histone H3Q5 (H3Q5ser) is a recently identified posttranslational modification of histones that acts as a permissive marker for gene activation in synergy with H3K4me3 during neuronal cell differentiation. However, any proteins that specifically recognize H3Q5ser remain unknown. Here, we found that WDR...
Congratulations to Dai Chen Rui for winning the second prize of the first Yonglian Biology Scholarship in 2020.
12-24,2020
Congratulations to ZhaoJie for winning the second prize of Excellent Wall Newspaper Award in the 2020 Annual Postgraduate Meeting of the Ministry of Health and Medicine.
12-19,2020
Congratulations to ZhangMin and Lancine for successfully completing their doctoral defense and obtaining their doctoral degree.
06-16,2020
Congrats to the publication of “Centromere targeting of Mis18 requires the interaction with DNA and H2A–H2B in fission yeast” in Cellular and Molecular Life Sciences.
04-21,2020
Centromere targeting of Mis18 requires the interaction with DNA and H2A–H2B in fission yeastFaithful chromosome segregation during mitosis requires the correct assembly of kinetochore on the centromere. CENP-A is a variant of histone H3, which specializes the centromere region on chromatin and mediates the kinetochore assembly. The Mis18 complex plays a critical role in initiating the centromere l...
